This study evaluated the feasibility of implementing the Tailored Activity Program for Hospitals (TAP-H) to improve engagement in patients with dementia admitted for behavioral disturbances. The model provides in-hospital sessions to develop activities tailored to patient interests and capabilities and train staff/families in their use. The study’s time series design with multiple behavioral observations, compared affective, verbal, and nonverbal behavioral responses in a standardized activity to treatment sessions. Results show that the TAP-H collaborative care model results in improved affect and reduced negative behaviors, and can be incorporated into routine hospital care and payment mechanisms.